On October 5, 2016, the American Heart Association, Verily Life Sciences LLC and AstraZeneca announced Dr. Calum MacRae as the leader of our One Brave Idea initiative. He beat out hundreds of other applicants from around the world to receive this landmark award that will provide support over a five-year period for a research project focused on uncovering the causes of heart disease, including previously unrecognized signals marking the transition from wellness to the earliest, yet still largely invisible stages of disease. Dr. MacRae is also the Chief of Cardiology at the Brigham and Women’s Hospital. His clinical interests include the management of inherited heart disease and cardiac involvement in systemic diseases. In addition, Dr. MacRae is a leading investigator at the Brigham and Women’s Hospital Genomics Center, a principal faculty member at the Cardiovascular Research Center and the Harvard Stem Cell Institute, and an associated member at the Broad Institute.